![]() ![]() ĭuring the COVID-19 pandemic, virus detection based on culture is an important tool for virus pathogenesis research, but the culture cycle is too long, so it is not suitable for the rapid detection of viruses related to acute infectious diseases. By the end of June 2020, there were nearly 10 million confirmed cases and nearly 5 million deaths of COVID-19, and the number of positive cases and deaths is still rising, posing a serious threat to international health. More than 3.5 million cases of laboratory-confirmed COVID-19 and 250,000 deaths worldwide have been reported globally in early May 2020. ![]() On 30 January 2020, WHO has declared the prevalence of COVID-19 is a Public Health Emergency of International Concern (PHEIC). The ongoing continuation and spread of the COVID-19 pose challenges for public health control. There are currently 7 CoVs (including SARS-CoV-2) that can cause human respiratory diseases, but to date, only SARS-CoV, MERS-CoV, and SARS-CoV-2 have caused a large outbreak with high mortality. Before the appearance of SARS-CoV-2, 6 HCoVs have been discovered by researchers, including HCoV-229E, HCoV-HKU1, HCoV-NL63, HCoV-OC43, Severe Acute Respiratory Syndrome (SARS) CoV and Middle East Respiratory Syndrome (MERS) CoV. The World Health Organization (WHO) announced that the official name of the disease caused by the virus is Coronavirus Disease 2019 (COVID-19).Ĭoronaviruses (CoVs) are enveloped viruses with a single-stranded, positive-sense RNA genome, which is the largest discovered genome of RNA virus. The International Committee on Taxonomy of Viruses (ICTV) has announced that the novel coronavirus is officially classified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus involved in the event was identified as the seventh coronavirus, becoming the third zoonotic human coronaviruses (HCoV) of the century, and posing serious threats to international health. This review shall guide for the diagnosis of COVID-19 caused by SARS-CoV-2.Ī novel virus caused an outbreak of pneumonia began from Wuhan, Hubei Province, China. ![]() This review will discuss the performance of different laboratory diagnostic tests and platforms, as well as suitable clinical samples for testing, and related biosafety protection. Point-of-care tests have the advantage of rapid, accurate, portable, low cost and non-specific device requirements, which provide great help for disease diagnosis and detection. Molecular tests are the basis for confirmation of COVID-19, but serological tests for SARS-CoV-2 are widely available and play an increasingly important role in understanding the epidemiology of the virus and in identifying populations at higher risk for infection. Rapid and early laboratory diagnosis of COVID-19 is the main focus of treatment and control. As of the end of 2020, there were nearly 10 million confirmed cases and nearly 5 million deaths associated with COVID-19. The outbreak of Coronavirus Disease-2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has threatened health worldwide. ![]()
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